Browsing by Subject "CDK9/CyclinT"
Now showing items 1-3 of 3
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Synthesis and biological evaluation of 7-azaindole-based chalcones and related compounds as protein kinase inhibitors
(North-West University (South-Africa), 2021)Protein phosphorylation is a major molecular mechanism through which proteins’ functions are regulated. Protein phosphorylation occurs through protein kinases, and it consists of the transfer of a phosphate group from a ... -
Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors
(Elsevier, 2020)Protein kinases are important drug targets, especially in the area of oncology. This paper reports the synthesis and biological evaluation of new 7-azaindole derivatives bearing benzocycloalkanone motifs as potential protein ... -
Synthesis and evaluation of C3 substituted chalcone-based derivatives of 7-azaindole as protein kinase inhibitors
(Wiley, 2020)Chalcones are a group of naturally occurring or synthetic compounds which possess a wide range of biological activities. In this paper, a series of twenty‐three 7‐azaindole‐chalcone hybrids (5a–w) were synthesized and ...