Browsing by Subject "Biodistribution"
Now showing items 1-9 of 9
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99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles
(Elsevier, 2018)The aim of this study was to establish the in vivo uptake and tissue distribution of 99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive 99mTc-MDP encapsulated into SLNs was administered ... -
An assessment of the biodistribution, biopersistence and toxicity of gold nanoparticles
(North-West University (South Africa) , Potchefstroom Campus, 2015)The interest in biomedical applications of gold nanoparticles (AuNPs) has increased dramatically in the last decade due to their ease of synthesis, unique surface and optical properties. The main driver of this surge in ... -
Biodistribution (as determined by the radiolabelled equivalent) of a gold(III) bis(pyrrolide-imine) Schiff base complex: a potential chemotherapeutic
(Wiley, 2013)The biodistribution of an N2N2 0 tetradentate gold(III) chelate, which is known to be cytotoxic towards a range of human cancer cell lines, was determined by a radiolabelled equivalent of the compound. The 198Au-labelled ... -
Biodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogue
(Springer, 2015)Dinuclearbisphosphinogold(I) dithiocarbamato, BPDTC, was previously found to have antitumour activity in vitro. 198Au radiolabelled BPDTC (radiochemical yield of 70 ± 6 % and radiochemical purity of[95 %) was used to ... -
Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration
(Elsevier, 2012)The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ... -
Evaluation of the effect of colloidal systems on biodistribution of selected prostate cancer radiopharmaceuticals
(North-West University (South-Africa), 2019)It has been reported that microemulsion (ME) delivery systems provide an opportunity to enhance the bioavailability and efficacy of a therapeutic agent whilst minimising side effects. The prostate-specific membrane antigen ... -
The in vitro and in vivo pharmacokinetic parameters of polylactic–co–glycolic acid nanoparticles encapsulating anti–tuberculosis drugs
(North-West University, 2012)Tuberculosis (TB) is an infectious, deadly disease, caused by Mycobacterium tuberculosis (M.tb). In 2010, there were 8,8 million incident cases of TB globally. South Africa currently has the third highest TB incident ... -
Preclinical assessment of 68Ga‐PSMA‐617 entrapped in a microemulsion delivery system for applications in prostate cancer PET/CT imaging
(Wiley, 2019)It has in recent years been reported that microemulsion (ME) delivery systems provide an opportunity to improve the efficacy of a therapeutic agent whilst minimising side effects and also offer the advantage of favourable ... -
Samarium oxide as a radiotracer to evaluate the in vivo biodistribution of PLGA nanoparticles
(Springer, 2015)Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim of ...