Browsing by Subject "Azithromycin"
Now showing items 1-8 of 8
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Amorphism and polymorphism of azithromycin
(North-West University, 2012)Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ... -
Amorphous azithromycin with improved aqueous solubility and intestinal membrane permeability
(Taylor & Francis, 2015)Azithromycin (AZM) is a poorly soluble macrolide antibacterial agent. Its low solubility is considered as the major contributing factor to its relatively low oral bioavailability. The aim of this study was to improve the ... -
In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum
(Springer Nature, 2012)The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been demonstrated. In this study, we investigated the enhancement of the ... -
In vitro antimalarial efficacy enhancement of selected antibiotics with PheroidTM technology
(North-West University, 2010)The Plasmodium falciparum parasite, carried by Anopheles mosquitoes, is currently a global problem due to the rising incidence of resistance of the parasite to available antimalaria drugs. Resistance and difficult treatment ... -
Investigation of the physico-chemical properties of amorphous solid-state forms of azithromycin
(North-West University (South Africa) , Potchefstroom Campus, 2016)Azithromycin is chemically modified from the macrolide, erythromycin and thereby shows improved efficacy and has more advantages above other macrolides. Azithromycin is currently the most prescribed and used macrolide ... -
Short- and long-term effects of orally administered azithromycin on Trypanosoma brucei brucei-infected mice
(Elsevier, 2019)Human African trypanosomosis (HAT) and animal African trypanosomosis (AAT) are diseases of economic importance in humans and animals that affect more than 36 African countries. The currently available trypanocidal drugs ... -
Stability of amorphous azithromycin in a tablet formulation
(2014)It is a well-known fact that drugs can exist in different solid-state forms. These solid-state forms can be either crystalline or amorphous. Furthermore, significant differences are identified between the different solid-state ... -
Water and the relationship to the crystal structure stability of azithromycin: thermal investigations of solvatomorphism, amorphism and polymorphism
(Springer, 2018)This study investigated the solid-state physical stabilities of azithromycin dihydrate (AZM-DH), thermally prepared anhydrate and hemihydrate modifications. Programmed thermal treatment of AZM-DH in DSC yielded the formation ...