Browsing by Subject "Atherosclerosis"
Now showing items 1-10 of 12
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Asymmetric dimethylarginine and l-homoarginine prospectively relate to carotid wall thickness in a South African cohort
(Springer, 2020)Background and aims The L-arginine derivatives asymmetric (ADMA) and symmetric dimethylarginine (SDMA), as well as L-homoarginine may have opposing effects in the pathogenesis of atherosclerosis. We aimed to investigate ... -
Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: a five-year prospective study
(Sage Publications Ltd, 2016)Background: Inconsistent findings are reported on whether insulin-like growth factor-1 (IGF-1) is protective or harmful in predicting hypertension, carotid wall thickness and mortality. We determined the five-year ... -
Carotid cross-sectional wall area is significantly associated with serum leptin levels, independent of body mass index: the SABPA studyent of body mass index: the SABPA study
(Japanese Society of HypertensionNature Publishing Group, 2012)Hypertension and obesity are serious health burdens in sub-Saharan Africa. Urbanized Africans seem to be more susceptible to the development of these diseases than Caucasians. Current research suggests that leptin may be ... -
Die verband tussen die fisieke-aktiwiteitsindeks en rook op die lipiedbeeld by mans (35-64 jaar) in 'n Suid-Afrikaanse stedelike gemeenskap
(North-West University (South Africa), 1999)The physical activity index and smoking and the lipid profile of men (35-64 years) in a South African urban community 1. Problem and purpose of this research The modern lifestyle, including cigarette smoking and physical ... -
The effects of vitamin C on the haemostatic system
(North-West University, 2003)Motivation: Cardiovascular disease (CVD) is one of the leading causes of mortality and morbidity in South Africa and worldwide. Dyslipidaemia and an increased coagulation state contribute to the development of CVD. The ... -
An ethnic comparison of arginine dimethylation and cardiometabolic factors in healthy black and white youth: the ASOS and African-PREDICT studies
(MDPI, 2020)Proteinic arginine dimethylation (PADiMe) is a major post-translational modification. Proteolysis of asymmetric and symmetric PADiMe products releases asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), ... -
Leptin and the vasculature in young adults: the African‐PREDICT study
(Wiley, 2019)Background and aim Information regarding the effect of leptin on the vasculature in young healthy adults at risk for cardiovascular disease development is limited. We therefore examined the associations between measures ... -
A longitudinal investigation of the cardiovascular health of a black South African cohort infected with the human immunodeficiency virus
(North-West University (South-Africa), 2021)Motivation - The human immunodeficiency virus (HIV) continues to be a global health concern, with an estimation of 38 million people living with HIV. Out of these 38 million people living with HIV, 70% are residing in ... -
Monocyte chemoattractant protein-1 and large artery structure and function in young individuals : the African-PREDICT study
(North-West University (South Africa) , Potchefstroom Campus, 2015)Motivation - In sub-Saharan Africa, the burden of cardiovascular diseases (CVD) is increasing at an alarming rate. This may be due to the rapid urbanisation of traditional black populations, leading to lifestyle changes ... -
New mtDNA association model, MutPred variant load, suggests individuals with multiple mildly deleterious mtDNA variants are more likely to suffer from atherosclerosis
(Frontiers Media, 2019)The etiology of common complex diseases is multifactorial, involving both genetic, and environmental factors. A role for mitochondrial dysfunction and mitochondrial DNA (mtDNA) variation has been suggested in the pathogenesis ...