Browsing by Subject "Amorphous"
Now showing items 1-10 of 16
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Amorphism and polymorphism of azithromycin
(North-West University, 2012)Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ... -
Amorphous azithromycin with improved aqueous solubility and intestinal membrane permeability
(Taylor & Francis, 2015)Azithromycin (AZM) is a poorly soluble macrolide antibacterial agent. Its low solubility is considered as the major contributing factor to its relatively low oral bioavailability. The aim of this study was to improve the ... -
Amorphous sulfadoxine: a physical stability and crystallization kinetics study
(Springer Nature, 2016)Poor aqueous solubility of drugs and the improvement thereof has always been a challenge for the pharmaceutical industry.With this, one of the focuses of the pharmaceutical research scientist involves investigating ... -
Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study
(Elsevier, 2016)The striking impact that different preparation methods have on the characteristics of amorphous solidstate forms has attracted considerable attention during the last two decades. The pursuit of more extensive knowledge ... -
The effect of solid-state forms on the topical delivery of roxithromycin
(2015)The skin is a very accessible and convenient route of administration for topical and systemic drugs (Williams, 2003:1). The only problem most formulators face is overcoming the barrier function of the stratum corneum, which ... -
The effect of temperature and moisture on the amorphous-to-crystalline transformation of stavudine
(Elsevier, 2009)Stavudine is a nucleoside reverse transcriptase inhibitor active against HIV, and is known to exist in two polymorphic forms designated as forms I and II, and a hydrate form III. An amorphous solid of stavudine was ... -
Investigation of the stabilising effects of niosomes on the amorphous forms of roxithromycin
(North-West University (South Africa), Potchefstroom Campus, 2018)The first aim of this research study was to determine the effect of the excipients used in the typical niosome preparation on the solid-state nature of three solid-state forms of roxithromycin. The second aim was to ascertain ... -
The physico-chemical properties and recrystallisation kinetics of selected amorphous active ingredients
(North-West University (South Africa) , Potchefstroom Campus, 2015)During the last two to three decades the application of amorphous solid-state forms within the pharmaceutical industry gained much interest. The rationale for this heightened interest is the increased aqueous solubility, ... -
Physicochemical properties of amorphous roxithromycin prepared by quench cooling of the melt or desolvation of a chloroform solvate
(Springer, 2012)Roxithromycin is a poorly soluble antibacterial drug. The aim of this study was to prepare and characterize an amorphous form of roxithromycin. The amorphous form was prepared by desolvation of its chloroform solvate, and ... -
The physico–chemical properties of spiramycin and clarithromycin
(2012)In most cases, organic materials exist in the solid phase as polymorphs, solvatomorphs or amorphous forms. Physico-chemical properties in the solid-state are all affected primarily in terms of dissolution, solubility, ...
