Browsing by Author "Caira, Mino R."
Now showing items 1-7 of 7
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Channel inclusion of primary alcohols in isostructural solvates of the antiretroviral nevirapine: an X-ray and thermal analysis study
Stieger, Nicole; Liebenberg, Wilna; Wessels, Johanna C.; Samsodien, Halima; Caira, Mino R. (Springer, 2010)X-ray structural and thermoanalytical data for a series of solvates 2–7 of the anti-HIV drug nevirapine containing primary alcohols CH3(CH2)nOH with n = 2–7 are reported. The structures of 2–7 are based on a common ... -
Co-crystals of the antiretroviral nevirapine: crystal structures, thermal analysis and dissolution behaviour
Caira, Mino R.; Liebenberg, Wilna; Stieger, Nicole; Aucamp, Marique; Bourne, Susan A. (RSC, 2012)Synthesis and physicochemical characterization of co-crystals of the antiretroviral drug nevirapine (NV) with the pharmaceutically acceptable co-formers saccharin, rac-tartaric acid, maleic acid, glutaric acid and salicylic ... -
Crystallization of toxic glycol solvates of rifampin from glycerin and propylene glycol contaminated with ethylene glycol or diethylene glycol
De Villiers, Melgardt M.; Strydom, Schalk J.; Liebenberg, Wilna; Caira, Mino R.; Li, Jinjing (ACS, 2011)This study was initiated when it was suspected that syringe blockage experienced upon administration of a compounded rifampin suspension was caused by the recrystallization of toxic glycol solvates of the drug. Single ... -
Influence of the composition of water/ethanol mixtures on the solubility and recrystallization of nevirapine
Stieger, Nicole; Liebenberg, Wilna; Tiedt, Louwrens R.; Wessels, Johanna C.; Caira, Mino R. (ACS, 2010)Anhydrous nevirapine was recrystallized from ethanol containing various amounts of water to determine its effects on the products obtained. The solubility of the anhydrous form was determined for each of the binary solvent ... -
The risk of recrystallization: changes to the toxicity and morphology of pyrimethamine
Perold, Zak; Brits, Marius; Caira, Mino R. (Canadian Society for Pharmaceutical Sciences, 2014)PURPOSE. Pyrimethamine, an anti-malarial agent known to exhibit solid state polymorphism, may be purified by means of recrystallization. Recrystallization may alter the solid state chemistry of pharmaceuticals, which may ... -
Solvatomorphism of the antibacterial dapsone: X-ray structures and thermal desolvation kinetics
Lemmer, Helanie; Stieger, Nicole; Liebenberg, Wilna; Caira, Mino R. (ACS, 2012)Three non-isostructural solvates of the antibacterial dapsone (DDS) containing dichloromethane [DDS•0.5(DCM)], 1,4-dioxane [DDS•DXN], and tetrahydrofuran [DDS•THF] were prepared and characterized by X-ray diffraction (XRD) ... -
Solvent inclusion by the anti-HIV drug nevirapine: X-ray structures and thermal decomposition of representative solvates
Caira, Mino R.; Stieger, Nicole; Liebenberg, Wilna; De Villiers, Melgardt M.; Samsodien, Halima (ACS, 2008)Five crystalline solvates of the anti-HIV drug Nevirapine (N), with compositions N·(ethyl acetate)0.5 (1), N·(dichloromethane)0.5 (2), N·(toluene)0.5 (3), N·(water)0.5 (4), and N·(1,4-dioxane)1.5 (5), were isolated and ...