Browsing by Author "Bach, Stéphane"

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Synthesis and biological evaluation of selected 7-azaindole derivatives as CDK9/Cyclin T and Haspin inhibitors

Pieterse, Lianie; Legoabe, Lesetja J.; Beteck, Richard M.; Josselin, Béatrice; Bach, Stéphane (Springer, 2020)

The 7-azaindole scaffold attracts attention due to its value in the design of inhibitors of diseases related protein kinases. However, this scaffold has not been evaluated against Haploid germ cell-specific nuclear protein ...
Synthesis and evaluation of C3 substituted chalcone-based derivatives of 7-azaindole as protein kinase inhibitors

Qhobosheane, Malikotsi A.; Legoabe, Lesetja J.; Beteck, Richard M.; Josselin, Béatrice; Bach, Stéphane (Wiley, 2020)

Chalcones are a group of naturally occurring or synthetic compounds which possess a wide range of biological activities. In this paper, a series of twenty‐three 7‐azaindole‐chalcone hybrids (5a–w) were synthesized and ...